Ontology highlight
ABSTRACT:
SUBMITTER: Yao L
PROVIDER: S-EPMC5627367 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Development (Cambridge, England) 20170731 17
Grainy head (Grh) is a conserved transcription factor (TF) controlling epithelial differentiation and regeneration. To elucidate Grh functions we identified embryonic Grh targets by ChIP-seq and gene expression analysis. We show that Grh controls hundreds of target genes. Repression or activation correlates with the distance of Grh-binding sites to the transcription start sites of its targets. Analysis of 54 Grh-responsive enhancers during development and upon wounding suggests cooperation with ...[more]