Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Genome-wide identification of Grainy head targets in Drosophila

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE102551 | GEO | 2017/08/12

SECONDARY ACCESSION(S): PRJNA398021

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Genome-wide identification of Grainy head targets in Drosophila [ChIP-seq]

Project description:Grainy head (Grh) is a conserved transcription factor (TF) controlling epithelial differentiation and regeneration. To elucidate Grh functions, we identified embryonic Grh targets by ChIP-seq and gene expression analysis. We show that Grh controls hundreds of target genes. Repression or activation correlates with the distance of Grh binding sites to the transcription start sites of its targets. Analysis of 54 Grh-responsive enhancers during development and upon wounding suggests cooperation with distinct TFs in different contexts. In the airways, Grh repressed genes encode key TFs involved in branching and cell differentiation. Reduction of the POU-domain TF, Vvl, (ventral veins lacking) largely ameliorates the airway morphogenesis defects of grh mutants. Vvl and Grh proteins additionally interact with each other and regulate a set of common enhancers during epithelial morphogenesis. We conclude that Grh and Vvl participate in a regulatory network controlling epithelial maturation.

2017-08-12 | GSE102550 | GEO

Genome-wide identification of Grainy head targets in Drosophila [gene expression]

2017-08-12 | GSE102549 | GEO

Genome-wide identification of Grainy head targets in Drosophila reveals regulatory interactions with the POU domain transcription factor Vvl.

Project description:Grainy head (Grh) is a conserved transcription factor (TF) controlling epithelial differentiation and regeneration. To elucidate Grh functions we identified embryonic Grh targets by ChIP-seq and gene expression analysis. We show that Grh controls hundreds of target genes. Repression or activation correlates with the distance of Grh-binding sites to the transcription start sites of its targets. Analysis of 54 Grh-responsive enhancers during development and upon wounding suggests cooperation with distinct TFs in different contexts. In the airways, Grh-repressed genes encode key TFs involved in branching and cell differentiation. Reduction of the POU domain TF Ventral veins lacking (Vvl) largely ameliorates the airway morphogenesis defects of grh mutants. Vvl and Grh proteins additionally interact with each other and regulate a set of common enhancers during epithelial morphogenesis. We conclude that Grh and Vvl participate in a regulatory network controlling epithelial maturation.

| S-EPMC5627367 | biostudies-literature

Genome-wide identification of Grainy head targets in Drosophila

Project description:Genome-wide identification of Grainy head targets in Drosophila

| PRJNA398021 | ENA

Genome-wide Identification of Neuronal Activity-regulated Genes in Drosophila

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-12-12 | GSE83976 | GEO

Genome-wide identification of AP-2α targets in bladder cells by RNA-seq

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-12-08 | GSE128716 | GEO

Genome-wide profiling of microRNAs and their targets in sweet orange

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-10-21 | E-GEOD-46765 | biostudies-arrayexpress

Gene expression profiling and genome-wide mapping of TEL-AML1 targets in acute leukemia

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-03-16 | E-GEOD-79268 | biostudies-arrayexpress

Genome-wide identification of FHY3 binding sites in Arabidopsis floral organ

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-07-28 | E-GEOD-69425 | biostudies-arrayexpress

Genome-wide identification of expression quantitative trait loci (eQTLs) in human heart

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-05-21 | E-GEOD-55232 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data