Ontology highlight
ABSTRACT:
SUBMITTER: Latallo MJ
PROVIDER: S-EPMC5628580 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Latallo M J MJ Cortina G A GA Faham S S Nakamoto R K RK Kasson P M PM
Chemical science 20170719 9
The CTX-M family of beta lactamases mediate broad-spectrum antibiotic resistance and are present in the majority of drug-resistant Gram-negative bacterial infections worldwide. Allosteric mutations that increase catalytic rates of these drug resistance enzymes have been identified in clinical isolates but are challenging to predict prospectively. We have used molecular dynamics simulations to predict allosteric mutants increasing CTX-M9 drug resistance, experimentally testing top mutants using m ...[more]