Identification of an unexpected shunt pathway product provides new insights into tirandamycin biosynthesis.
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ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC5628624 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
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Identification of an unexpected shunt pathway product provides new insights into tirandamycin biosynthesis.
Zhang Xingwang X Li Zhong Z Du Lei L Chlipala George E GE Lopez Patricia C PC Zhang Wei W Sherman David H DH Li Shengying S
Tetrahedron letters 20161119 52
Tirandamycin K (<b>7</b>), the first linear 7,13;9,13-diseco-tirandamycin derivative, was isolated from the <i>tamI</i> (encoding the TamI P450 monooxygenase) disruption mutant strain (<i>ΔtamI</i>) of marine <i>Streptomyces</i> sp. 307-9. Its chemical structure with relative and absolute configurations was elucidated by a combination of extensive spectroscopic analyses and biosynthetic inferences. Structural elucidation of this unusual compound provides new insights into tirandamycin biosynthes ...[more]
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