Genetic epidemiology and Mendelian randomization for informing disease therapeutics: Conceptual and methodological challenges.
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ABSTRACT:
SUBMITTER: Paternoster L
PROVIDER: S-EPMC5628782 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Publications
Genetic epidemiology and Mendelian randomization for informing disease therapeutics: Conceptual and methodological challenges.
Paternoster Lavinia L Tilling Kate K Davey Smith George G
PLoS genetics 20171005 10
The past decade has been proclaimed as a hugely successful era of gene discovery through the high yields of many genome-wide association studies (GWAS). However, much of the perceived benefit of such discoveries lies in the promise that the identification of genes that influence disease would directly translate into the identification of potential therapeutic targets, but this has yet to be realized at a level reflecting expectation. One reason for this, we suggest, is that GWAS, to date, have g ...[more]
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