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Influence of the milling parameters on the nucleophilic substitution reaction of activated ?-cyclodextrins.

ABSTRACT: The present work focuses on the mechanochemical preparation of industrially important ?-cyclodextrin (CD) derivatives. Activated CDs have been reacted with nitrogen and sulfur nucleophiles using a planetary mill equipped with stainless steel, zirconia and glass milling tools of different sizes. It is shown that the milling frequency and the number as well as the size of the milling balls have an effect on the nucleophilic reaction.

SUBMITTER: Jicsinszky L

PROVIDER: S-EPMC5629382 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Influence of the milling parameters on the nucleophilic substitution reaction of activated β-cyclodextrins.

Jicsinszky László L Tuza Kata K Cravotto Giancarlo G Porcheddu Andrea A Delogu Francesco F Colacino Evelina E

Beilstein journal of organic chemistry 20170907

The present work focuses on the mechanochemical preparation of industrially important β-cyclodextrin (CD) derivatives. Activated CDs have been reacted with nitrogen and sulfur nucleophiles using a planetary mill equipped with stainless steel, zirconia and glass milling tools of different sizes. It is shown that the milling frequency and the number as well as the size of the milling balls have an effect on the nucleophilic reaction. ...[more]

PMID: 29062408

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