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ABSTRACT:
SUBMITTER: Benner C
PROVIDER: S-EPMC5630179 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Benner Christian C Havulinna Aki S AS Järvelin Marjo-Riitta MR Salomaa Veikko V Ripatti Samuli S Pirinen Matti M
American journal of human genetics 20170921 4
During the past few years, various novel statistical methods have been developed for fine-mapping with the use of summary statistics from genome-wide association studies (GWASs). Although these approaches require information about the linkage disequilibrium (LD) between variants, there has not been a comprehensive evaluation of how estimation of the LD structure from reference genotype panels performs in comparison with that from the original individual-level GWAS data. Using population genotype ...[more]