Ontology highlight
ABSTRACT:
SUBMITTER: Li B
PROVIDER: S-EPMC5630306 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Li Bin B Zhang Guangsen G Li Cui C Li Ruijuan R Lu Jingchen J He Zhengxi Z Wang Quan Q Peng Zhenzi Z Wang Jun J Dong Yeping Y Zhang Chunfang C Tan Jie Qiong JQ Bahri Nacef N Wang Yuexiang Y Duan Chaojun C
Oncotarget 20160819 39
The Fip1-like1 (FIP1L1)-platelet-derived growth factor receptor alpha (PDGFRA) (F/P) oncogene can cause chronic eosinophilic leukemia (CEL), but requires IL-5 cytokine participation. In this study, we investigate the mechanism of F/P in collaboration with IL-5 in CEL. The results showed that Lyn, a key effector in the IL-5-motivated eosinophil production, is extensively activated in F/P-positive CEL cells. Lyn can associate and phosphorylate IL-5 receptor α (IL-5RA) in F/P-positive cells. Moreov ...[more]