Ontology highlight
ABSTRACT:
SUBMITTER: Liu RB
PROVIDER: S-EPMC5630418 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Liu Rong-Bin RB Guo Jian-Gui JG Liu Tian-Ze TZ Guo Cheng-Cheng CC Fan Xin-Xiang XX Zhang Xiao X Hu Wei-Han WH Cai Xiu-Yu XY
Oncotarget 20170619 39
The NOTCH1 signaling pathway is crucial for T-cell development, and NOTCH1 and/or FBXW7 mutations are frequently detected in T-cell acute lymphoblastic leukemia (T-ALL). We performed a systematic review and meta-analysis of 18 randomized controlled trials (RCTs) to assess the prognostic impact of mutations in the NOTCH1 pathway. After retrieving relevant articles from PubMed, EMBASE, and the Cochrane Library, we investigated overall survival (OS) and event-free survival (EFS) with hazard ratios ...[more]