Ontology highlight
ABSTRACT:
SUBMITTER: Andrews CD
PROVIDER: S-EPMC5633264 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Andrews Chasity D CD Luo Yang Y Sun Ming M Yu Jian J Goff Arthur J AJ Glass Pamela J PJ Padte Neal N NN Huang Yaoxing Y Ho David D DD
Molecular therapy. Methods & clinical development 20170920
Monoclonal antibodies (mAbs) have wide clinical utility, but global access is limited by high costs and impracticalities associated with repeated passive administration. Here, we describe an optimized electroporation-based DNA gene transfer platform technology that can be utilized for production of functional mAbs in vivo, with the potential to reduce costs and administration burdens. We demonstrate that multiple mAbs can be simultaneously expressed at protective concentrations for a protracted ...[more]