Ontology highlight
ABSTRACT:
SUBMITTER: Krahling V
PROVIDER: S-EPMC9931551 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Krähling Verena V Erbar Stephanie S Kupke Alexandra A Nogueira Sara S SS Walzer Kerstin C KC Berger Hendrik H Dietzel Erik E Halwe Sandro S Rohde Cornelius C Sauerhering Lucie L Aragão-Santiago Letícia L Moreno Herrero Jorge J Witzel Sonja S Haas Heinrich H Becker Stephan S Sahin Ugur U
Molecular therapy : the journal of the American Society of Gene Therapy 20221027 2
Emerging and re-emerging viruses, such as Zaire Ebola virus (EBOV), pose a global threat and require immediate countermeasures, including the rapid development of effective vaccines that are easy to manufacture. Synthetic self-amplifying RNAs (saRNAs) attend to these needs, being safe and strong immune stimulators that can be inexpensively produced in large quantities, using cell-free systems and good manufacturing practice. Here, the first goal was to develop and optimize an anti-EBOV saRNA-bas ...[more]