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Crystallization via tubing microfluidics permits both in situ and ex situ X-ray diffraction.

ABSTRACT: A microfluidic platform was used to address the problems of obtaining diffraction-quality crystals and crystal handling during transfer to the X-ray diffractometer. Crystallization conditions of a protein of pharmaceutical interest were optimized and X-ray data were collected both in situ and ex situ.

SUBMITTER: Gerard CJJ 

PROVIDER: S-EPMC5633925 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Crystallization via tubing microfluidics permits both in situ and ex situ X-ray diffraction.

Gerard Charline J J CJJ   Ferry Gilles G   Vuillard Laurent M LM   Boutin Jean A JA   Chavas Leonard M G LMG   Huet Tiphaine T   Ferte Nathalie N   Grossier Romain R   Candoni Nadine N   Veesler Stéphane S  

Acta crystallographica. Section F, Structural biology communications 20171002 Pt 10

A microfluidic platform was used to address the problems of obtaining diffraction-quality crystals and crystal handling during transfer to the X-ray diffractometer. Crystallization conditions of a protein of pharmaceutical interest were optimized and X-ray data were collected both in situ and ex situ. ...[more]

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