Ontology highlight
ABSTRACT:
SUBMITTER: Gebregiworgis T
PROVIDER: S-EPMC5634392 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Gebregiworgis Teklab T Purohit Vinee V Shukla Surendra K SK Tadros Saber S Chaika Nina V NV Abrego Jaime J Mulder Scott E SE Gunda Venugopal V Singh Pankaj K PK Powers Robert R
Journal of proteome research 20170830 10
Pancreatic cancer cells overexpressing Mucin 1 (MUC1) rely on aerobic glycolysis and, correspondingly, are dependent on glucose for survival. Our NMR metabolomics comparative analysis of control (S2-013.Neo) and MUC1-overexpressing (S2-013.MUC1) cells demonstrates that MUC1 reprograms glutamine metabolism upon glucose limitation. The observed alteration in glutamine metabolism under glucose limitation was accompanied by a relative decrease in the proliferation of MUC1-overexpressing cells compar ...[more]