Ontology highlight
ABSTRACT:
SUBMITTER: Shukla SK
PROVIDER: S-EPMC5533091 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Shukla Surendra K SK Purohit Vinee V Mehla Kamiya K Gunda Venugopal V Chaika Nina V NV Vernucci Enza E King Ryan J RJ Abrego Jaime J Goode Gennifer D GD Dasgupta Aneesha A Illies Alysha L AL Gebregiworgis Teklab T Dai Bingbing B Augustine Jithesh J JJ Murthy Divya D Attri Kuldeep S KS Mashadova Oksana O Grandgenett Paul M PM Powers Robert R Ly Quan P QP Lazenby Audrey J AJ Grem Jean L JL Yu Fang F Matés José M JM Asara John M JM Kim Jung-Whan JW Hankins Jordan H JH Weekes Colin C Hollingsworth Michael A MA Serkova Natalie J NJ Sasson Aaron R AR Fleming Jason B JB Oliveto Jennifer M JM Lyssiotis Costas A CA Cantley Lewis C LC Berim Lyudmyla L Singh Pankaj K PK
Cancer cell 20170701 1
Poor response to cancer therapy due to resistance remains a clinical challenge. The present study establishes a widely prevalent mechanism of resistance to gemcitabine in pancreatic cancer, whereby increased glycolytic flux leads to glucose addiction in cancer cells and a corresponding increase in pyrimidine biosynthesis to enhance the intrinsic levels of deoxycytidine triphosphate (dCTP). Increased levels of dCTP diminish the effective levels of gemcitabine through molecular competition. We als ...[more]