Ontology highlight
ABSTRACT:
SUBMITTER: Shukla SK
PROVIDER: S-EPMC5533091 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Cancer cell 20170701 1
Poor response to cancer therapy due to resistance remains a clinical challenge. The present study establishes a widely prevalent mechanism of resistance to gemcitabine in pancreatic cancer, whereby increased glycolytic flux leads to glucose addiction in cancer cells and a corresponding increase in pyrimidine biosynthesis to enhance the intrinsic levels of deoxycytidine triphosphate (dCTP). Increased levels of dCTP diminish the effective levels of gemcitabine through molecular competition. We als ...[more]