Ontology highlight
ABSTRACT:
SUBMITTER: Yang J
PROVIDER: S-EPMC5634921 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Dalton transactions (Cambridge, England : 2003) 20171001 39
A combination of reaction coordinate computations, resonance Raman spectroscopy, spectroscopic computations, and hydrogen bonding investigations have been used to understand the importance of substrate orientation along the xanthine oxidase reaction coordinate. Specifically, 4-thiolumazine and 2,4-dithiolumazine have been used as reducing substrates for xanthine oxidase to form stable enzyme-product charge transfer complexes suitable for spectroscopic study. Laser excitation into the near-infrar ...[more]