Ontology highlight
ABSTRACT:
SUBMITTER: Brown-Marshall CD
PROVIDER: S-EPMC2838496 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Brown-Marshall Christina D CD Diebold Adrienne R AR Solomon Edward I EI
Biochemistry 20100201 6
Isopenicillin N synthase (IPNS) can have both oxidase and oxygenase activity depending on the substrate. For the native substrate, ACV, oxidase activity exists; however, for the substrate analogue ACOV, which lacks an amide nitrogen, IPNS exhibits oxygenase activity. The potential energy surfaces for the O-O bond elongation and cleavage were calculated for three different reactions: homolytic cleavage via traditional Fenton chemistry, heterolytic cleavage, and nucleophilic attack. These surfaces ...[more]