Ontology highlight
ABSTRACT:
SUBMITTER: Bayro MJ
PROVIDER: S-EPMC5636003 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20160907 37
Maturation of HIV-1 requires disassembly of the Gag polyprotein lattice, which lines the viral membrane in the immature state, and subsequent assembly of the mature capsid protein lattice, which encloses viral RNA in the mature state. Metastability of the immature lattice has been proposed to depend on the existence of a structurally ordered, α-helical segment spanning the junction between capsid (CA) and spacer peptide 1 (SP1) subunits of Gag, a segment that is dynamically disordered in the mat ...[more]