Ontology highlight
ABSTRACT:
SUBMITTER: McCurley NP
PROVIDER: S-EPMC5636061 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
McCurley Nathanael P NP Domi Arban A Basu Rahul R Saunders Kevin O KO LaBranche Celia C CC Montefiori David C DC Haynes Barton F BF Robinson Harriet L HL
PloS one 20171011 10
Here we report the construction, antigenicity and initial immunogenicity testing of DNA and modified vaccinia Ankara (MVA) vaccines expressing virus-like particles (VLPs) displaying sequential clade C Envelopes (Envs) that co-evolved with the elicitation of broadly neutralizing antibodies (bnAbs) to the CD4 binding site (CD4bs) in HIV-infected individual CH0505. The VLP-displayed Envs showed reactivity for conformational epitopes displayed on the receptor-binding form of Env. Two inoculations of ...[more]