Ontology highlight
ABSTRACT:
SUBMITTER: Sonawane YA
PROVIDER: S-EPMC5636177 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Sonawane Yogesh A YA Taylor Margaret A MA Napoleon John Victor JV Rana Sandeep S Contreras Jacob I JI Natarajan Amarnath A
Journal of medicinal chemistry 20160603 19
Cyclin dependent kinase (CDK) inhibitors have been the topic of intense research for nearly 2 decades due to their widely varied and critical functions within the cell. Recently CDK9 has emerged as a druggable target for the development of cancer therapeutics. CDK9 plays a crucial role in transcription regulation; specifically, CDK9 mediated transcriptional regulation of short-lived antiapoptotic proteins is critical for the survival of transformed cells. Focused chemical libraries based on a pl ...[more]