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IL-21 Receptor Signaling Is Essential for Optimal CD4+ T Cell Function and Control of Mycobacterium tuberculosis Infection in Mice.


ABSTRACT: In this study, we determined the role of IL-21R signaling in Mycobacterium tuberculosis infection, using IL-21R knockout (KO) mice. A total of 50% of M. tuberculosis H37Rv-infected IL-21R KO mice died in 6 mo compared with no deaths in infected wild type (WT) mice. M. tuberculosis-infected IL-21R KO mice had enhanced bacterial burden and reduced infiltration of Ag-specific T cells in lungs compared with M. tuberculosis-infected WT mice. Ag-specific T cells from the lungs of M. tuberculosis-infected IL-21R KO mice had increased expression of T cell inhibitory receptors, reduced expression of chemokine receptors, proliferated less, and produced less IFN- ?, compared with Ag-specific T cells from the lungs of M. tuberculosis-infected WT mice. T cells from M. tuberculosis-infected IL-21R KO mice were unable to induce optimal macrophage responses to M. tuberculosis. This may be due to a decrease in the Ag-specific T cell population. We also found that IL-21R signaling is associated with reduced expression of a transcriptional factor Eomesodermin and enhanced functional capacity of Ag-specific T cells of M. tuberculosis-infected mice. The sum of our findings suggests that IL-21R signaling is essential for the optimal control of M. tuberculosis infection.

SUBMITTER: Cheekatla SS 

PROVIDER: S-EPMC5636679 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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IL-21 Receptor Signaling Is Essential for Optimal CD4<sup>+</sup> T Cell Function and Control of <i>Mycobacterium tuberculosis</i> Infection in Mice.

Cheekatla Satyanarayana Swamy SS   Tripathi Deepak D   Venkatasubramanian Sambasivan S   Paidipally Padmaja P   Welch Elwyn E   Tvinnereim Amy R AR   Nurieva Roza R   Vankayalapati Ramakrishna R  

Journal of immunology (Baltimore, Md. : 1950) 20170830 8


In this study, we determined the role of IL-21R signaling in <i>Mycobacterium tuberculosis</i> infection, using IL-21R knockout (KO) mice. A total of 50% of <i>M. tuberculosis</i> H37Rv<b>-</b>infected IL-21R KO mice died in 6 mo compared with no deaths in infected wild type (WT) mice. <i>M. tuberculosis</i><b>-</b>infected IL-21R KO mice had enhanced bacterial burden and reduced infiltration of Ag-specific T cells in lungs compared with <i>M. tuberculosis</i><b>-</b>infected WT mice. Ag-specifi  ...[more]

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