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Synthesis of 2'-deoxy-9-deaza nucleosides using Heck methodology.

ABSTRACT: During the synthesis of a series of 2'-deoxy-9-deaza nucleosides using Heck methodology, the necessity for a pyrrole protecting group was discovered. The results of this brief study revealed that the benzyloxymethyl (BOM) group proved optimal, and Heck coupling using Jeffery conditions increased the coupling yield significantly. The results are reported herein.

SUBMITTER: Temburnikar K

PROVIDER: S-EPMC5638437 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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Synthesis of 2'-deoxy-9-deaza nucleosides using Heck methodology.

Temburnikar Kartik K Brace Kelin K Seley-Radtke Katherine L KL

The Journal of organic chemistry 20130705 14

During the synthesis of a series of 2'-deoxy-9-deaza nucleosides using Heck methodology, the necessity for a pyrrole protecting group was discovered. The results of this brief study revealed that the benzyloxymethyl (BOM) group proved optimal, and Heck coupling using Jeffery conditions increased the coupling yield significantly. The results are reported herein. ...[more]

PMID: 23806030

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