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ABSTRACT:
SUBMITTER: Penjarla S
PROVIDER: S-EPMC7576186 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20201021 24
Various tetrazole and oxadiazole C-nucleoside analogues were synthesized starting from pure α- or β-glycosyl-cyanide. The synthesis of glycosyl-cyanide as key precursor was optimized on gram-scale to furnish crystalline starting material for the assembly of C-nucleosides. Oxadizole C-nucleosides were synthesized via two independent routes. First, the glycosyl-cyanide was converted into an amidoxime which upon ring closure offered an alternative pathway for the assembly of 1,2,4-oxadizoles in an ...[more]