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ABSTRACT: Aim
To examine the association of genetic polymorphisms (-308)G/A TNFα, (+250)A/G Ltα, (+36)A/G TNFR1, (+1663)A/G TNFR2 with the development of primary open angle glaucoma (POAG) among people in Central Russia.Methods
The study sample included 443 individuals, of which 252 patients with POAG and 191 individuals in the control group. Genotyping of (-308)G/A TNFα, (+250)A/G Ltα, (+36)A/G TNFR1, (+1663)A/G TNFR2 was performed using polymerase chain reaction. The distribution of alleles and genotypes of the studied DNA markers in the groups was examined by 2×2 contingency tables and χ2 with the Yates's correction for continuity and odds ratios (OR) with 95% confidence intervals (CI).Results
Allele (-308)G TNFα (Р=0.01, OR=1.78, 95%CI 1.12-2.85) was identified as a risk factor for POAG. Homozygotes (-308) AA TNFα are at a lowest risk for development of the disease (Р=0.01, OR=0.0005). The following combination of genetic variants of cytokines were associated with a reduced risk of POAG: (+1663)A TNFR2 and (+250)G Ltα (OR=0.34).Conclusion
Genetic polymorphisms (-308)G/A TNFα, (+250)A/G Ltα, (+1663)A/G TNFR2 associated with the development of POAG in the population of Central Russia.
SUBMITTER: Tikunova E
PROVIDER: S-EPMC5638967 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Tikunova Evgeniya E Ovtcharova Veronika V Reshetnikov Evgeny E Dvornyk Volodymyr V Polonikov Alexey A Bushueva Olga O Churnosov Mikhail M
International journal of ophthalmology 20171018 10
<h4>Aim</h4>To examine the association of genetic polymorphisms (-308)G/A <i>TNFα</i>, (+250)A/G <i>Ltα</i>, (+36)A/G <i>TNFR1</i>, (+1663)A/G <i>TNFR</i>2 with the development of primary open angle glaucoma (POAG) among people in Central Russia.<h4>Methods</h4>The study sample included 443 individuals, of which 252 patients with POAG and 191 individuals in the control group. Genotyping of (-308)G/A <i>TNFα</i>, (+250)A/G <i>Ltα</i>, (+36)A/G <i>TNFR1</i>, (+1663)A/G <i>TNFR</i>2 was performed u ...[more]