Ontology highlight
ABSTRACT: Aim
To investigate the correlation between lumican (LUM) gene and high myopia in a Southern Chinese population.Methods
The study comprised of 95 high myopia patients with a spherical equivalent ≤-6.5 diopters (D). The control group recruited 95 individuals with a spherical equivalent ranging from -0.5 D to +0.5 D. Direct sequencing was used to detect the single nucleotide polymorphisms (SNPs) of LUM gene in coding region. Genotype distributions were tested for Hardy-Weinberg disequilibrium. Genotypic and allelic frequencies were analyzed through Chi-square test or Fisher's exact test.Results
We identified 3 SNPs of the LUM gene: LUM c.32 (rs577456426), LUM c.507 (rs17853500) and LUM c.849 (rs181915277). Among the three SNPs, the genotype and allele frequencies of rs17853500 showed a significant difference between patients and control subjects (P<0.05). However, there were no significant differences in rs181915277 and rs577456426 between the two groups (P>0.05).Conclusion
LUM c.507 polymorphism may be a risk factor for the pathogenesis of high myopia in the Southern Chinese population.
SUBMITTER: Wang GF
PROVIDER: S-EPMC5638971 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Wang Gui-Fang GF Ji Qing-Shan QS Qi Bing B Yu Guo-Cheng GC Liu Lian L Zhong Jing-Xiang JX
International journal of ophthalmology 20171018 10
<h4>Aim</h4>To investigate the correlation between lumican (LUM) gene and high myopia in a Southern Chinese population.<h4>Methods</h4>The study comprised of 95 high myopia patients with a spherical equivalent ≤-6.5 diopters (D). The control group recruited 95 individuals with a spherical equivalent ranging from -0.5 D to +0.5 D. Direct sequencing was used to detect the single nucleotide polymorphisms (SNPs) of LUM gene in coding region. Genotype distributions were tested for Hardy-Weinberg dise ...[more]