Ontology highlight
ABSTRACT:
SUBMITTER: Bonham LW
PROVIDER: S-EPMC5639900 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Bonham Luke W LW Sirkis Daniel W DW Fan Jia J Aparicio Renan E RE Tse Marian M Ramos Eliana Marisa EM Wang Qing Q Coppola Giovanni G Rosen Howard J HJ Miller Bruce L BL Yokoyama Jennifer S JS
Neurocase 20170201 1
Rare variation in the TREM2 gene is associated with a broad spectrum of neurodegenerative disorders including Alzheimer's disease (AD). TREM2 encodes a receptor expressed in microglia which is thought to influence neurodegeneration by sensing damage signals and regulating neuroinflammation. Many of the variants reported to be associated with AD, including the rare R47H variant, were discovered in populations of European ancestry and have not replicated in diverse populations from other genetic b ...[more]