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Recurrent wheeze and its relationship with lung function and airway inflammation in preschool children: a cross-sectional study in South Korea.

ABSTRACT: BACKGROUND:Relationship between recurrent wheeze and airway function and inflammation in preschool children is not fully known. OBJECTIVE:To investigate the relationship between recurrent wheeze and airway inflammation, lung function, airway hyper-reactivity (AHR) and atopy in preschool children. DESIGN:Observational study, comparing forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and mid-forced expiratory flow (FEF25%-75%), dose-response slope (DRS), exhaled nitric oxide (eNO) and atopic sensitisation between children with recurrent wheeze and those without. SETTING:Population-based, cross-sectional study in Seoul and the Gyeonggi province of Korea conducted as a government-funded programme to perform standardised measurement of the prevalence of allergic diseases, and related factors, in preschool children. PARTICIPANTS:900 children aged 4-6 years. PRIMARY AND SECONDARY OUTCOME MEASURES: eNO, FEV1/FVC, FEF25%-75%, DRS, atopic sensitisation and allergic diseases. METHODS:Children completed the modified International Study of Asthma and Allergies in Childhood questionnaire and underwent eNO assessments, spirometry, methacholine bronchial provocation tests and skin prick tests. Recurrent wheeze was defined as having a lifetime wheeze of more than three episodes, based on the questionnaire. The frequency of hospitalisation and emergency room visits was also obtained by means of the questionnaire. 'Current' wheeze was defined as having symptoms or treatments within the past 12 months. RESULTS:The prevalence of recurrent wheeze was 13.4%. Children with recurrent wheeze showed a higher prevalence of lifetime or current allergic rhinitis (p=0.01?and p=0.002, respectively) and lifetime atopic dermatitis (p=0.007). Children with recurrent wheeze showed lower FEV1/FVC (p=0.033) and FEF25%-75% (p=0.004), and higher eNO levels (p=0.013) than those without recurrent wheeze. However, the DRS, prevalence of atopic sensitisation and serum IgE levels were not significantly different between the two groups. CONCLUSIONS:Recurrent wheeze in preschool children may be associated with airway inflammation and diminished airway function, but not with AHR or atopy.

SUBMITTER: Soh JE

PROVIDER: S-EPMC5640071 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Recurrent wheeze and its relationship with lung function and airway inflammation in preschool children: a cross-sectional study in South Korea.

Soh Ji Eun JE Kim Kyung-Moon KM Kwon Ji-Won JW Kim Hyung Young HY Seo Ju-Hee JH Kim Hyo-Bin HB Lee So-Yeon SY Jang Gwang-Cheon GC Song Dae-Jin DJ Kim Woo Kyung WK Jung Young-Ho YH Hong Soo-Jong SJ Shim Jung Yeon JY

BMJ open 20171008 10

<h4>Background</h4>Relationship between recurrent wheeze and airway function and inflammation in preschool children is not fully known.<h4>Objective</h4>To investigate the relationship between recurrent wheeze and airway inflammation, lung function, airway hyper-reactivity (AHR) and atopy in preschool children.<h4>Design</h4>Observational study, comparing forced expiratory volume in 1 s (FEV<sub>1</sub>), forced vital capacity (FVC) and mid-forced expiratory flow (FEF<sub>25%-75%</sub>), dose-re ...[more]

PMID: 28993393

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Project description:BackgroundDue to high prevalence and serious impacts, childhood caries represents a public health issue. Behavioural risk factors such as locus of health control have been implicated in the development of the disease; however their association with childhood caries has not been thoroughly studied. The aim of this cross-sectional survey was to assess the relationship between parental locus of health control and caries experience and untreated caries of their preschool children in a representative sample in Czech Republic, adjusting for relevant sociodemographic characteristics.MethodsA representative sample of 285 preschool children and their parents was recruited. Study data included children's dental status recorded in nurseries and parental questionnaires with 13 attitudinal items regarding locus of control (LoC) in caries prevention. The association between parental locus of control and children's caries experience and level of untreated caries was analysed using logistic regression, adjusting for the effect of key sociodemographic variables.ResultsThere was a statistically highly significant linear trend between increased parental LoC and higher probability of the children to be free from untreated caries, independent from the effect of sociodemographic variables of children and parents. A similar highly statistically significant trend, although not entirely linear, and independent from sociodemographic variables was observed with respect to the chance of the children to be free from caries experience with increasing strength of parental LoC. After full adjustment, children in the strongest parental LoC quintile were 2.81 (1.23-6.42, p< 0.05) times more likely to be free from untreated caries in comparison to the weakest parental LoC quintile and 2.32 (1.02-5.25, p< 0.05) times more likely to be free from caries experience in comparison to the weakest parental LoC quintile.ConclusionThe findings support the hypothesis that higher internal parental LoC is associated with better control of both untreated caries and caries experience in their preschool children and highlight that a more internal LoC within the family is advantageous in the prevention of dental caries.

Dataset Information

Recurrent wheeze and its relationship with lung function and airway inflammation in preschool children: a cross-sectional study in South Korea.

Publications

Recurrent wheeze and its relationship with lung function and airway inflammation in preschool children: a cross-sectional study in South Korea.

Similar Datasets

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