Dataset Information

P. falciparum infection and maternofetal antibody transfer in malaria-endemic settings of varying transmission.

ABSTRACT:

Introduction

During pregnancy, immunoglobulin G (IgG) is transferred from the mother to the fetus, providing protection from disease in early infancy. Plasmodium falciparum infections may reduce maternofetal antibody transfer efficiency, but mechanisms remain unclear.

Methods

Mother-cord paired serum samples collected at delivery from Papua New Guinea (PNG) and the Thailand-Myanmar Border Area (TMBA) were tested for IgG1 and IgG3 to four P. falciparum antigens and measles antigen, as well as total serum IgG. Multivariable linear regression was conducted to assess the association of peripheral P. falciparum infection during pregnancy or placental P. falciparum infection assessed at delivery with maternofetal antibody transfer efficiency. Path analysis assessed the extent to which associations between P. falciparum infection and antibody transfer were mediated by gestational age at delivery or levels of maternal total serum IgG.

Results

Maternofetal antibody transfer efficiency of IgG1 and IgG3 was lower in PNG compared to TMBA (mean difference in cord antibody levels (controlling for maternal antibody levels) ranged from -0.88 to 0.09, median of -0.20 log2 units). Placental P. falciparum infections were associated with substantially lower maternofetal antibody transfer efficiency in PNG primigravid women (mean difference in cord antibody levels (controlling for maternal antibody levels) ranged from -0.62 to -0.10, median of -0.36 log2 units), but not multigravid women. The lower antibody transfer efficiency amongst primigravid women with placental infection was only partially mediated by gestational age at delivery (proportion indirect effect ranged from 0% to 18%), whereas no mediation effects of maternal total serum IgG were observed.

Discussion

Primigravid women may be at risk of impaired maternofetal antibody transport with placental P. falciparum infection. Direct effects of P. falciparum on the placenta, rather than earlier gestational age and elevated serum IgG, are likely responsible for the majority of the reduction in maternofetal antibody transfer efficiency with placental infection.

SUBMITTER: McLean ARD

PROVIDER: S-EPMC5640245 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Publications

P. falciparum infection and maternofetal antibody transfer in malaria-endemic settings of varying transmission.

McLean Alistair R D ARD Stanisic Danielle D McGready Rose R Chotivanich Kesinee K Clapham Caroline C Baiwog Francesca F Pimanpanarak Mupawjay M Siba Peter P Mueller Ivo I King Christopher L CL Nosten François F Beeson James G JG Rogerson Stephen S Simpson Julie A JA Fowkes Freya J I FJI

PloS one 20171013 10

<h4>Introduction</h4>During pregnancy, immunoglobulin G (IgG) is transferred from the mother to the fetus, providing protection from disease in early infancy. Plasmodium falciparum infections may reduce maternofetal antibody transfer efficiency, but mechanisms remain unclear.<h4>Methods</h4>Mother-cord paired serum samples collected at delivery from Papua New Guinea (PNG) and the Thailand-Myanmar Border Area (TMBA) were tested for IgG1 and IgG3 to four P. falciparum antigens and measles antigen, ...[more]

PMID: 29028827

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Dataset Information

P. falciparum infection and maternofetal antibody transfer in malaria-endemic settings of varying transmission.

Introduction

Methods

Results

Discussion

Publications

P. falciparum infection and maternofetal antibody transfer in malaria-endemic settings of varying transmission.

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