Ontology highlight
ABSTRACT:
SUBMITTER: Zhao X
PROVIDER: S-EPMC5642541 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Zhao Xiaofeng X Huang Lu L Xu Wanwan W Chen Xiaoyan X Shen Yan Y Zeng Wenjie W Chen Xiao X
Oncotarget 20170726 41
Ovarian cancer is the most lethal gynaecological malignancy. Recurrence and subsequent resistance to chemotherapy have become major obstacles to treating these diseases. In the present study, we showed that a natural withanolide isolated from the plant Physalis pubescens L. (Solanaceae), Physapubescin B, exhibited potent anti-tumor activity against ovarian cancer cells. Physapubescin B promoted apoptosis, induced cell-cycle arrest and inhibited invasion of ES-2 and A2780 cells. Physapubescin B t ...[more]