Ontology highlight
ABSTRACT:
SUBMITTER: Manandhar S
PROVIDER: S-EPMC5642574 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Manandhar Sarala S Kim Chang-Gu CG Lee Sun-Hee SH Kang Soo Hyun SH Basnet Nikita N Lee You Mie YM
Oncotarget 20170731 41
Cancer stem cells (CSCs) are associated with cancer recurrence following radio/chemotherapy owing to their high resistance to therapeutic intervention. In this study, we investigated the role of exostoxin 1 (EXT1), an endoplasmic reticulum (ER)-residing type II transmembrane glycoprotein, in cancer cell stemness. DNA microarray analysis revealed that doxorubicin-resistant MCF7/ADR cells have high levels of EXT1 expression compared to its parental cell line, MCF7. These cells showed significantly ...[more]