Cell softness regulates tumorigenicity and stemness of cancer cells.
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ABSTRACT:
SUBMITTER: Lv J
PROVIDER: S-EPMC7809788 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Publications
Cell softness regulates tumorigenicity and stemness of cancer cells.
Lv Jiadi J Liu Yaoping Y Cheng Feiran F Li Jiping J Zhou Yabo Y Zhang Tianzhen T Zhou Nannan N Li Cong C Wang Zhenfeng Z Ma Longfei L Liu Mengyu M Zhu Qiang Q Liu Xiaohan X Tang Ke K Ma Jingwei J Zhang Huafeng H Xie Jing J Fang Yi Y Zhang Haizeng H Wang Ning N Liu Yuying Y Huang Bo B
The EMBO journal 20201204 2
Identifying and sorting highly tumorigenic and metastatic tumor cells from a heterogeneous cell population is a daunting challenge. Here, we show that microfluidic devices can be used to sort marker-based heterogeneous cancer stem cells (CSC) into mechanically stiff and soft subpopulations. The isolated soft tumor cells (< 400 Pa) but not the stiff ones (> 700 Pa) can form a tumor in immunocompetent mice with 100 cells per inoculation. Notably, only the soft, but not the stiff cells, isolated fr ...[more]
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