Ontology highlight
ABSTRACT:
SUBMITTER: Mele V
PROVIDER: S-EPMC5642581 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Mele Valentina V Sokol Lena L Kölzer Viktor Hendrik VH Pfaff Dennis D Muraro Manuele Giuseppe MG Keller Irene I Stefan Zahnd Z Centeno Irene I Terracciano Luigi Maria LM Dawson Heather H Zlobec Inti I Iezzi Giandomenica G Lugli Alessandro A
Oncotarget 20170803 41
In colorectal cancer (CRC), RHAMM is an independent adverse prognostic factor. The aim of the study was therefore to investigate on the role of RHAMM as a potential direct driver of cell proliferation and migration in CRC cell lines and to identify pathways dependent on RHAMM in human CRC. Proliferation, cell cycle alterations and invasive capacity were tested in two RHAMM- and control- knockdown CRC cell lines by flow cytometry and <i>in vitro</i> assays. Tumorigenicity and metastasis formation ...[more]