Ontology highlight
ABSTRACT:
SUBMITTER: Nedvetzki S
PROVIDER: S-EPMC539795 | biostudies-literature | 2004 Dec
REPOSITORIES: biostudies-literature
Nedvetzki Shlomo S Gonen Erez E Assayag Nathalie N Reich Reuven R Williams Richard O RO Thurmond Robin L RL Huang Jing-Feng JF Neudecker Birgit A BA Wang Fu-Sheng FS Turley Eva A EA Naor David D
Proceedings of the National Academy of Sciences of the United States of America 20041213 52
We report here that joint inflammation in collagen-induced arthritis is more aggravated in CD44-knockout mice than in WT mice, and we provide evidence for molecular redundancy as a causal factor. Furthermore, we show that under the inflammatory cascade, RHAMM (receptor for hyaluronan-mediated motility), a hyaluronan receptor distinct from CD44, compensates for the loss of CD44 in binding hyaluronic acid, supporting cell migration, up-regulating genes involved with inflammation (as assessed by mi ...[more]