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Patterns of failure in limited-stage small cell lung cancer: Implications of TNM stage for prophylactic cranial irradiation.


ABSTRACT: BACKGROUND AND PURPOSE:The relationship between tumor-node-metastasis (TNM) stage and patterns of failure in limited-stage small cell lung cancer (LS-SCLC) remains unclear. We hypothesized that TNM stage predicts brain metastasis risk, and could inform the use of prophylactic cranial irradiation. MATERIAL AND METHODS:We reviewed 283 patients with stage I-IIIB SCLC. Competing-risks regression was used to analyze local, distant, and brain failure. Multivariate analysis was used to evaluate the effect of treatment and clinical factors on failure and OS. RESULTS:Patients with stage I or II SCLC (35% of cohort) had significantly better survival and lower risk of distant and brain metastasis, compared with stage III patients. The 5-year cumulative incidence of brain metastasis for stage I/II and III were 12% and 26%, respectively. Stage had no correlation with local failure. On multivariate analysis, stage was independently prognostic for survival, distant metastasis risk, and brain metastasis risk. CONCLUSIONS:TNM staging predicts likelihood of distant metastasis, brain metastasis, and survival in LS-SCLC. This supports the routine use of TNM staging in clinical practice. The lower risk of brain metastasis in stage I and II SCLC suggests that prophylactic cranial irradiation could play a more limited role in treatment of early-stage disease.

SUBMITTER: Wu AJ 

PROVIDER: S-EPMC5643234 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Patterns of failure in limited-stage small cell lung cancer: Implications of TNM stage for prophylactic cranial irradiation.

Wu Abraham J AJ   Gillis Andrea A   Foster Amanda A   Woo Kaitlin K   Zhang Zhigang Z   Gelblum Daphna Y DY   Downey Robert J RJ   Rosenzweig Kenneth E KE   Ong Leonard L   Perez Carmen A CA   Pietanza M Catherine MC   Krug Lee L   Rudin Charles M CM   Rimner Andreas A  

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20170801 1


<h4>Background and purpose</h4>The relationship between tumor-node-metastasis (TNM) stage and patterns of failure in limited-stage small cell lung cancer (LS-SCLC) remains unclear. We hypothesized that TNM stage predicts brain metastasis risk, and could inform the use of prophylactic cranial irradiation.<h4>Material and methods</h4>We reviewed 283 patients with stage I-IIIB SCLC. Competing-risks regression was used to analyze local, distant, and brain failure. Multivariate analysis was used to e  ...[more]

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