Genomics alterations of metastatic and primary tissues across 15 cancer types.
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ABSTRACT:
SUBMITTER: Liu G
PROVIDER: S-EPMC5643378 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
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Genomics alterations of metastatic and primary tissues across 15 cancer types.
Liu Gang G Zhan Xiaohui X Dong Chuanpeng C Liu Lei L
Scientific reports 20171016 1
Metastasis is an important event for cancer evolution and prognosis. In this article, we analyzed the differences in genomic alterations between primary and metastatic tissues at hotspot regions in 15 cancer types and 10,456 samples. Differential somatic mutations at the amino acid, protein domain and gene levels, mutational exclusiveness, and copy number variations were identified in these cancers, while no significant nucleotide and gene fusion differences were detected. The homogeneity and he ...[more]
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