Dataset Information

Correlation of Plasma EGF with Striatal Dopamine Transporter Availability in Healthy Subjects.

ABSTRACT: We aimed to evaluate the association between plasma epidermal growth factor (EGF) and the availability of dopamine transporter (DAT) measured from 123I-FP-CIT single-photon emission computed tomography in healthy controls in this study. Volume of interest template was applied to measure specific binding ratios (SBRs) of caudate nucleus, putamen, and striatum representing DAT availability as follows; SBR?=?(target- cerebellum)/cerebellum. Plasma EGF was negatively correlated with the availabilities of both caudate nucleus (r?=?-0.261, p?=?0.019), and putamen (r?=?-0.341, p?=?0.002). After dividing subjects according to Apo E genotyping, DAT availability of caudate nucleus of Apo e4 non-carriers (n?=?60) showed the positive correlation with cerebrospinal fluid (CSF) ?-synuclein (r?=?0.264, p?=?0.042). Plasma EGF was negatively correlated with DAT availabilities of Apo e4 non-carriers. Further studies are needed to clarify underlying mechanisms of this phenomenon.

SUBMITTER: Pak K

PROVIDER: S-EPMC5643386 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Correlation of Plasma EGF with Striatal Dopamine Transporter Availability in Healthy Subjects.

Pak Kyoungjune K Shin Seunghyeon S Kim So Jung SJ Kim Keunyoung K Kim Bum Soo BS Kim Seong Jang SJ Kim In Joo IJ

Scientific reports 20171016 1

We aimed to evaluate the association between plasma epidermal growth factor (EGF) and the availability of dopamine transporter (DAT) measured from <sup>123</sup>I-FP-CIT single-photon emission computed tomography in healthy controls in this study. Volume of interest template was applied to measure specific binding ratios (SBRs) of caudate nucleus, putamen, and striatum representing DAT availability as follows; SBR = (target- cerebellum)/cerebellum. Plasma EGF was negatively correlated with the a ...[more]

PMID: 29038492

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Project description:BackgroundCoffee is the most widely consumed psychostimulant worldwide. Emerging evidence indicates that coffee consumption habit significantly reduces the risk of developing Parkinson's disease (PD). However, the effect of coffee consumption on nigrostriatal dopaminergic neurodegeneration is still largely unknown. We therefore aim to investigate the role of coffee consumption in nigrostriatal dopaminergic neurodegeneration using dopamine transporter (DAT) imaging in PD and healthy controls (HC).MethodsA total of 138 PD patients and 75 HC with questionnaires about coffee consumption, and DAT scans were recruited from the Parkinson's Progression Markers Initiative cohort. Demographic, clinical, and striatal DAT characteristics were compared across subgroups of current, former, and never coffee consumers in PD and HC, respectively. Furthermore, partial correlation analyses were performed to determine whether there was a relationship between coffee cups consumed per day and striatal DAT characteristics in each striatal region. In addition, the factors that may have influenced the loss of nigrostriatal dopaminergic neurons were included in multiple linear regression analyses to identify significant contributing factors to DAT availability in each striatal region.ResultsPD patients had lower DAT availability in each striatal region than HC (p < 0.001). In PD patients, there were significant differences in DAT availability in the caudate (p = 0.008, Bonferroni corrected) across three PD subgroups. Specifically, post hoc tests showed that current coffee consumers had significantly lower DAT availability in the caudate than former coffee consumers (p = 0.01) and never coffee consumers (p = 0.022). In HC, there were significant differences in DAT availability in the caudate (p = 0.031, Bonferroni uncorrected) across three HC subgroups. Specifically, post hoc tests showed that current coffee consumers had significantly lower DAT availability in the caudate than former coffee consumers (p = 0.022). Moreover, correlation analysis revealed that cups per day were negatively correlated with DAT availability in the caudate in current consumers of PD patients (r = - 0.219, p = 0.047). In addition, multiple linear regression analyses showed that current coffee consumption remained an independent predictor of decreased DAT availability in the caudate in PD patients and HC.ConclusionsThis study demonstrates that current coffee consumption is associated with decreased striatal DAT availability in the caudate. However, the effects of caffeine on striatal DAT may fade and disappear after quitting coffee consumption.Trial registrationClinicalTrials.gov, NCT01141023.

Dataset Information

Correlation of Plasma EGF with Striatal Dopamine Transporter Availability in Healthy Subjects.

Publications

Correlation of Plasma EGF with Striatal Dopamine Transporter Availability in Healthy Subjects.

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