Ontology highlight
ABSTRACT:
SUBMITTER: Luthra T
PROVIDER: S-EPMC5643545 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Luthra Tania T Agarwal Rahul R Estari Mamidala M Adepally Uma U Sen Subhabrata S
Scientific reports 20171016 1
α-glucosidase is an essential enzyme located at the brush border of intestines. It is an important therapeutic target for type II diabetes. Herein we have designed a library of novel α-arylketones as inhibitors of α-glucosidase (yeast origin) via scaffold hopping and bioisosteric modification of known inhibitors of α-glucosidase. The design was validated through molecular docking that revealed strong binding interactions of the newly designed compounds against α-glucosidase. A library comprising ...[more]