Ontology highlight
ABSTRACT:
SUBMITTER: Maddock J
PROVIDER: S-EPMC5643555 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Maddock Jane J Zhou Ang A Cavadino Alana A Kuźma Elżbieta E Bao Yanchun Y Smart Melissa C MC Saum Kai-Uwe KU Schöttker Ben B Engmann Jorgen J Kjærgaard Marie M Karhunen Ville V Zhan Yiqiang Y Lehtimäki Terho T Rovio Suvi P SP Byberg Liisa L Lahti Jari J Marques-Vidal Pedro P Sen Abhijit A Perna Laura L Schirmer Henrik H Singh-Manoux Archana A Auvinen Juha J Hutri-Kähönen Nina N Kähönen Mika M Kilander Lena L Räikkönen Katri K Melhus Håkan H Ingelsson Erik E Guessous Idris I Petrovic Katja E KE Schmidt Helena H Schmidt Reinhold R Vollenweider Peter P Lind Lars L Eriksson Johan G JG Michaëlsson Karl K Raitakari Olli T OT Hägg Sara S Pedersen Nancy L NL Herzig Karl-Heinz KH Järvelin Marjo-Riitta MR Veijola Juha J Kivimaki Mika M Jorde Rolf R Brenner Hermann H Kumari Meena M Power Chris C Llewellyn David J DJ Hyppönen Elina E
Scientific reports 20171016 1
The causal nature of the association between hypovitaminosis D and poor cognitive function in mid- to later-life is uncertain. Using a Mendelian randomisation(MR) approach, we examined the causal relationship between 25(OH)D and cognitive function. Data came from 172,349 participants from 17 cohorts. DHCR7(rs12785878), CYP2R1 rs12794714) and their combined synthesis score were chosen to proxy 25(OH)D. Cognitive tests were standardised into global and memory scores. Analyses were stratified by 25 ...[more]