Ontology highlight
ABSTRACT:
SUBMITTER: Takahashi H
PROVIDER: S-EPMC5799201 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Takahashi Hannah H Cornish Alex J AJ Sud Amit A Law Philip J PJ Kinnersley Ben B Ostrom Quinn T QT Labreche Karim K Eckel-Passow Jeanette E JE Armstrong Georgina N GN Claus Elizabeth B EB Il'yasova Dora D Schildkraut Joellen J Barnholtz-Sloan Jill S JS Olson Sara H SH Bernstein Jonine L JL Lai Rose K RK Schoemaker Minouk J MJ Simon Matthias M Hoffmann Per P Nöthen Markus M MM Jöckel Karl-Heinz KH Chanock Stephen S Rajaraman Preetha P Johansen Christoffer C Jenkins Robert B RB Melin Beatrice S BS Wrensch Margaret R MR Sanson Marc M Bondy Melissa L ML Turnbull Clare C Houlston Richard S RS
Scientific reports 20180205 1
To examine for a causal relationship between vitamin D and glioma risk we performed an analysis of genetic variants associated with serum 25-hydroxyvitamin D (25(OH)D) levels using Mendelian randomisation (MR), an approach unaffected by biases from confounding. Two-sample MR was undertaken using genome-wide association study data. Single nucleotide polymorphisms (SNPs) associated with 25(OH)D levels were used as instrumental variables (IVs). We calculated MR estimates for the odds ratio (OR) for ...[more]