Ontology highlight
ABSTRACT:
SUBMITTER: Zheng M
PROVIDER: S-EPMC5643737 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Zheng Mingfeng M Shi Shiyuan S Zheng Qi Q Wang Yifan Y Ying Xiaozhang X Jin Yanghui Y
Bioscience reports 20171017 5
Osteoarthritis (OA) is a complex disease that is induced by many genetic risk variants and other factors. To examine the role of toll-like receptor 9 (TLR-9) in OA patients, we conducted a case-control study involving 215 knee OA (KOA) patients and 215 controls in a Chinese population. Genotyping with a custom-by-design 48-Plex single nucleotide polymorphism Scan™ Kit showed the <i>TLR</i>-9 gene rs187084 polymorphism was associated with an increased risk of KOA. Stratification analyses further ...[more]