Ontology highlight
ABSTRACT:
SUBMITTER: Tehrani KHME
PROVIDER: S-EPMC5644712 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Tehrani Kamaleddin Haj Mohammad Ebrahim KHME Martin Nathaniel I NI
ACS infectious diseases 20170828 10
The prevalence of infections caused by metallo-β-lactamase (MBL) expressing Gram-negative bacteria has grown at an alarming rate in recent years. Despite the fact that MBLs can deactivate virtually all β-lactam antibiotics, there are as of yet no approved drugs available that inhibit their activity. We here examine the ability of previously reported thiol-based MBL inhibitors to synergize with meropenem and cefoperazone against a panel of Gram-negative carbapenem-resistant isolates expressing di ...[more]