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High Rates of New Delhi Metallo-?-Lactamase Carbapenemase Genes in Multi-Drug Resistant Gram-Negative Bacteria in Nicaragua.

ABSTRACT: Antimicrobial resistance (AMR) is a global public health crisis. Much of the burden of AMR in resource-limited settings remains unknown. This pilot study characterized clinical isolates of multidrug-resistant Gram-negative rods (MDR-GNRs) from Nicaragua. New Delhi metallo-?-lactamase (NDM) carbapenemase genes were detected in 60% of isolates. Enterobacteriaceae had the highest rates of NDM detection, with 92% (50/54 isolates) positive by polymerase chain reaction (PCR). Pulsed-field gel electrophoresis (PFGE) analysis revealed patterns of clustering among isolates by two factors: plasmid profiles and year of culture. These findings of very high rates of NDM-carbapenemase genes in MDR-GNRs from hospitals throughout Nicaragua are alarming. Further research is needed to determine clinical and epidemiologic factors associated with multidrug-resistant isolates and to guide interventions to limit further spread.

SUBMITTER: Dretler AW 

PROVIDER: S-EPMC7008350 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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High Rates of New Delhi Metallo-β-Lactamase Carbapenemase Genes in Multi-Drug Resistant Gram-Negative Bacteria in Nicaragua.

Dretler Alexandra W AW   Avila Julissa J   Sandoval Lira Lissette L   García Rener Marcia M   Burger-Calderon Raquel R   Hargita Michelle N MN   Page Alexander M AM   Waggoner Jesse J JJ   Satola Sarah W SW  

The American journal of tropical medicine and hygiene 20200201 2

Antimicrobial resistance (AMR) is a global public health crisis. Much of the burden of AMR in resource-limited settings remains unknown. This pilot study characterized clinical isolates of multidrug-resistant Gram-negative rods (MDR-GNRs) from Nicaragua. New Delhi metallo-β-lactamase (NDM) carbapenemase genes were detected in 60% of isolates. <i>Enterobacteriaceae</i> had the highest rates of NDM detection, with 92% (50/54 isolates) positive by polymerase chain reaction (PCR). Pulsed-field gel e  ...[more]

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