Application of spin echoes in the regime of weak dephasing to T1 -mapping of the lung.

ABSTRACT: PURPOSE:This work presents an approach to mapping the entire lung's proton density and T1 within a single breath-hold and analyzes the apparent T1 when exciting with a spin echo generating pulse in comparison to a standard gradient echo acquisition. METHODS:An inversion-recovery SNAPSHOT-FLASH sequence with a stack-of-stars k-space readout with a golden angle increment was modified to use a spin echo generating radiofrequency-pulse for excitation. Data of five volunteers were acquired on a 3T scanner and image reconstruction was performed by an iterative algorithm adopted from MR-Fingerprinting. RESULTS:The feasibility of acquiring quantitative maps of the entire lung with a resolution of 5 × 5 × 10 mm within 7.5 s is demonstrated. It is shown that the proposed spin echo forming radiofrequency-pulse increases the apparent proton density compared to a rectangular pulse. Further, the apparent T1 is reduced in the spin echo case compared to the gradient echo sequence. CONCLUSION:The proposed spin echo based method results in T1 maps that are comparable to the ones that were acquired with ultra-short echo time sequences elsewhere. The T1 shortening is believed to originate from increased signal contributions of the extra vascular compartment, which has a short T2? and T1 . Magn Reson Med 79:960-967, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

SUBMITTER: Asslander J 

PROVIDER: S-EPMC5645219 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature