Ontology highlight
ABSTRACT:
SUBMITTER: Bogusz J
PROVIDER: S-EPMC5645348 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Bogusz Jozefina J Zrubek Karol K Rembacz Krzysztof P KP Grudnik Przemyslaw P Golik Przemyslaw P Romanowska Malgorzata M Wladyka Benedykt B Dubin Grzegorz G
Scientific reports 20171017 1
PIM1 is an oncogenic kinase overexpressed in a number of cancers where it correlates with poor prognosis. Several studies demonstrated that inhibition of PIM1 activity is an attractive strategy in fighting overexpressing cancers, while distinct structural features of ATP binding pocket make PIM1 an inviting target for the design of selective inhibitors. To facilitate development of specific PIM1 inhibitors, in this study we report three crystal structures of ATP-competitive inhibitors at the ATP ...[more]