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Identification of quinones as novel PIM1 kinase inhibitors.

ABSTRACT: PIM1 is a proto-oncogene encoding the serine/threonine PIM1 kinase. PIM1 kinase plays important roles in regulating aspects of cell cycle progression, apoptosis resistance, and has been implicated in the development of such malignancies as prostate cancer and acute myeloid leukemia among others. Knockout of PIM1 kinase in mice has been shown to be non-lethal without any obvious phenotypic changes, making it an attractive therapeutic target. Our investigation of anthraquinones as kinase inhibitors revealed a series of quinone analogs showing high selectivity for inhibition of the PIM kinases. Molecular modeling studies were used to identify key interactions and binding poses of these compounds within the PIM1 binding pocket. Compounds 1, 4, 7 and 9 inhibited the growth of DU-145 prostate cancer cell lines with a potency of 8.21?M, 4.06?M, 3.21?M and 2.02?M.

SUBMITTER: Schroeder RL

PROVIDER: S-EPMC4899092 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature

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Identification of quinones as novel PIM1 kinase inhibitors.

Schroeder Richard L RL Goyal Navneet N Bratton Melyssa M Townley Ian I Pham Nancy A NA Tram Phan P Stone Treasure T Geathers Jasmine J Nguyen Kathy K Sridhar Jayalakshmi J

Bioorganic & medicinal chemistry letters 20160428 13

PIM1 is a proto-oncogene encoding the serine/threonine PIM1 kinase. PIM1 kinase plays important roles in regulating aspects of cell cycle progression, apoptosis resistance, and has been implicated in the development of such malignancies as prostate cancer and acute myeloid leukemia among others. Knockout of PIM1 kinase in mice has been shown to be non-lethal without any obvious phenotypic changes, making it an attractive therapeutic target. Our investigation of anthraquinones as kinase inhibitor ...[more]

PMID: 27173800

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