Ontology highlight
ABSTRACT:
SUBMITTER: Nejadmoghaddam MR
PROVIDER: S-EPMC5645454 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Nejadmoghaddam Mohammad-Reza MR Zarnani Amir-Hassan AH Ghahremanzadeh Ramin R Ghods Roya R Mahmoudian Jafar J Yousefi Maryam M Nazari Mahboobeh M Ghahremani Mohammad Hossein MH Abolhasani Maryam M Anissian Ali A Mahmoudi Morteza M Dinarvand Rassoul R
Scientific reports 20171017 1
Our recent findings strongly support the idea of PLAC1 being as a potential immunotherapeutic target in prostate cancer (PCa). Here, we have generated and evaluated an anti-placenta-specific1 (PLAC1)-based antibody drug conjugate (ADC) for targeted immunotherapy of PCa. Prostate cancer cells express considerable levels of PLAC1. The Anti-PLAC1 clone, 2H12C12, showed high reactivity with recombinant PLAC1 and selectivity recognized PLAC1 in prostate cancer cells but not in LS180 cells, the negati ...[more]