Ontology highlight
ABSTRACT:
SUBMITTER: Huang Y
PROVIDER: S-EPMC5647250 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Huang Yining Y Salinas Nichole D ND Chen Edwin E Tolia Niraj H NH Gross Michael L ML
Journal of the American Society for Mass Spectrometry 20170905 11
Plasmodium vivax Duffy Binding Protein (PvDBP) is a promising vaccine candidate for P. vivax malaria. Recently, we reported the epitopes on PvDBP region II (PvDBP-II) for three inhibitory monoclonal antibodies (2D10, 2H2, and 2C6). In this communication, we describe the combination of native mass spectrometry and ion mobility (IM) with collision induced unfolding (CIU) to study the conformation and stabilities of three malarial antigen-antibody complexes. These complexes, when collisionally acti ...[more]