Dataset Information

Untangling the Hairball: Fitness-Based Asymptotic Reduction of Biological Networks.

ABSTRACT: Complex mathematical models of interaction networks are routinely used for prediction in systems biology. However, it is difficult to reconcile network complexities with a formal understanding of their behavior. Here, we propose a simple procedure (called ?¯) to reduce biological models to functional submodules, using statistical mechanics of complex systems combined with a fitness-based approach inspired by in silico evolution. The ?¯ algorithm works by putting parameters or combination of parameters to some asymptotic limit, while keeping (or slightly improving) the model performance, and requires parameter symmetry breaking for more complex models. We illustrate ?¯ on biochemical adaptation and on different models of immune recognition by T cells. An intractable model of immune recognition with close to a hundred individual transition rates is reduced to a simple two-parameter model. The ?¯ algorithm extracts three different mechanisms for early immune recognition, and automatically discovers similar functional modules in different models of the same process, allowing for model classification and comparison. Our procedure can be applied to biological networks based on rate equations using a fitness function that quantifies phenotypic performance.

SUBMITTER: Proulx-Giraldeau F

PROVIDER: S-EPMC5647575 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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Publications

Untangling the Hairball: Fitness-Based Asymptotic Reduction of Biological Networks.

Proulx-Giraldeau Félix F Rademaker Thomas J TJ François Paul P

Biophysical journal 20171001 8

Complex mathematical models of interaction networks are routinely used for prediction in systems biology. However, it is difficult to reconcile network complexities with a formal understanding of their behavior. Here, we propose a simple procedure (called ϕ¯) to reduce biological models to functional submodules, using statistical mechanics of complex systems combined with a fitness-based approach inspired by in silico evolution. The ϕ¯ algorithm works by putting parameters or combination of para ...[more]

PMID: 29045882

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Project description:Boolean networks have been widely used as models for gene regulatory networks, signal transduction networks, or neural networks, among many others. One of the main difficulties in analyzing the dynamics of a Boolean network and its sensitivity to perturbations or mutations is the fact that it grows exponentially with the number of nodes. Therefore, various approaches for simplifying the computations and reducing the network to a subset of relevant nodes have been proposed in the past few years. We consider a recently introduced method for reducing a Boolean network to its most determinative nodes that yield the highest information gain. The determinative power of a node is obtained by a summation of all mutual information quantities over all nodes having the chosen node as a common input, thus representing a measure of information gain obtained by the knowledge of the node under consideration. The determinative power of nodes has been considered in the literature under the assumption that the inputs are independent in which case one can use the Bahadur orthonormal basis. In this article, we relax that assumption and use a standard orthonormal basis instead. We use techniques of Hilbert space operators and harmonic analysis to generate formulas for the sensitivity to perturbations of nodes, quantified by the notions of influence, average sensitivity, and strength. Since we work on finite-dimensional spaces, our formulas and estimates can be and are formulated in plain matrix algebra terminology. We analyze the determinative power of nodes for a Boolean model of a signal transduction network of a generic fibroblast cell. We also show the similarities and differences induced by the alternative complete orthonormal basis used. Among the similarities, we mention the fact that the knowledge of the states of the most determinative nodes reduces the entropy or uncertainty of the overall network significantly. In a special case, we obtain a stronger result than in previous works, showing that a large information gain from a set of input nodes generates increased sensitivity to perturbations of those inputs.

Dataset Information

Untangling the Hairball: Fitness-Based Asymptotic Reduction of Biological Networks.

Publications

Untangling the Hairball: Fitness-Based Asymptotic Reduction of Biological Networks.

Similar Datasets

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