Ontology highlight
ABSTRACT:
SUBMITTER: Sawant OB
PROVIDER: S-EPMC5647869 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Sawant Onkar B OB Horton Amanda M AM Zucaro Olivia F OF Chan Ricky R Bonilha Vera L VL Samuels Ivy S IS Rao Sujata S
Cell reports 20171001 3
Circadian clocks regulate various aspects of photoreceptor physiology, but their contribution to photoreceptor development and function is unclear. Cone photoreceptors are critical for color vision. Here, we define the molecular function of circadian activity within cone photoreceptors and reveal a role for the clock genes Bmal1 and Per2 in regulating cone spectral identity. ChIP analysis revealed that BMAL1 binds to the promoter region of the thyroid hormone (TH)-activating enzyme type 2 iodoth ...[more]