Ontology highlight
ABSTRACT:
SUBMITTER: Forero A
PROVIDER: S-EPMC5647870 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Forero Adriana A Fenstermacher Katherine K Wohlgemuth Nicholas N Nishida Andrew A Carter Victoria V Smith Elise A EA Peng Xinxia X Hayes Melissa M Francis Doreen D Treanor John J Morrison Juliet J Klein Sabra L SL Lane Andrew A Katze Michael G MG Pekosz Andrew A
Vaccine 20170928 45
The host innate immune response to influenza virus is a key determinant of pathogenic outcomes and long-term protective immune responses against subsequent exposures. Here, we present a direct contrast of the host responses in primary differentiated human nasal epithelial cell (hNEC) cultures following infection with either a seasonal H3N2 influenza virus (WT) or the antigenically-matched live-attenuated vaccine (LAIV) strain. Comparison of the transcriptional profiles obtained 24 and 36h post-i ...[more]