Dataset Information

Gravidity is not associated with telomere length in a biracial cohort of middle-aged women: The Coronary Artery Risk Development in Young Adults (CARDIA) study.

ABSTRACT:

Objective

Having experienced 2-3 births is associated with reduced mortality versus women with <2 or ?4 births. The effect of 2-3 births on lifespan may be associated with delayed cellular aging. We hypothesized telomere length, a marker of cellular aging, would be longer in women who had 2-3 pregnancies.

Methods

Leukocyte telomere length was measured using quantitative real-time polymerase chain reaction in 620 women in CARDIA at the year 15 and 20 exams, expressed as the ratio of telomere repeat copy number to single-copy gene copy number (T/S). Number of pregnancies at the time of telomere length measurement was obtained (mean age = 41±0.1 years, average gravidity = 2.64±0.1 pregnancies). Participants were divided into 4 groups by number of pregnancies: 0, 1, 2-3, and ?4, to test for differences in telomere length by gravidity group.

Results

The mean and SD for telomere length was 0.98 ± 0.20 T/S in the whole cohort. There were no differences in mean telomere length between groups; 0.98±0.02 T/S in women with 0 pregnancies, 1.01±0.02 T/S in women with 1 pregnancy, 0.97±0.01 T/S in women with 2-3 pregnancies, and 0.99±0.02 T/S in women with ?4 pregnancies (p = 0.51). We defined high-risk (shorter) telomere length as ?25th percentile, and low-risk (longer) telomere length as ?75 percentile. There were no differences in the prevalence of high-risk or low-risk telomere length between gravidity groups.

Conclusions

Gravidity was not associated with telomere length in early middle age; the protective association of 2-3 births may act through other mechanisms.

SUBMITTER: Lane-Cordova AD

PROVIDER: S-EPMC5648190 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Gravidity is not associated with telomere length in a biracial cohort of middle-aged women: The Coronary Artery Risk Development in Young Adults (CARDIA) study.

Lane-Cordova Abbi D AD Puterman Eli E Gunderson Erica P EP Chan Cheeling C Hou Lifang L Carnethon Mercedes M

PloS one 20171019 10

<h4>Objective</h4>Having experienced 2-3 births is associated with reduced mortality versus women with <2 or ≥4 births. The effect of 2-3 births on lifespan may be associated with delayed cellular aging. We hypothesized telomere length, a marker of cellular aging, would be longer in women who had 2-3 pregnancies.<h4>Methods</h4>Leukocyte telomere length was measured using quantitative real-time polymerase chain reaction in 620 women in CARDIA at the year 15 and 20 exams, expressed as the ratio o ...[more]

PMID: 29049398

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Dataset Information

Gravidity is not associated with telomere length in a biracial cohort of middle-aged women: The Coronary Artery Risk Development in Young Adults (CARDIA) study.

Objective

Methods

Results

Conclusions

Publications

Gravidity is not associated with telomere length in a biracial cohort of middle-aged women: The Coronary Artery Risk Development in Young Adults (CARDIA) study.

Similar Datasets

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